Topic: cortical function

N-methyl-D-aspartate (NMDA) receptors are critical for cortical function and their dysfunctions are implicated in psychiatric disorders. Previous modeling studies focused on their role in generating long-timescale neuronal dynamics for working memory or evidence accumulation. Less is known about how NMDA-mediated synapses shape oscillatory dynamics in local field potentials (LFPs) or non-invasive E/MEG recordings, and how changes in NMDA transmission can be inferred from such measures of mass activity. To address these issues, we developed a recurrent network model of excitatory (E) and inhibi

Hormones regulate brain function to achieve adaptive cognitive and behavioural responses. Consequently, disruption of sex hormone signaling may underlie some aspects of sex and gender bias in psychiatric and developmental brain disorder frequency and presentation. Currently, the basis by which sex steroid hormones (e.g. estradiol) alter sensory processing and cortical function is largely unexplored, as most research focuses on impacts within the hypothalamus and limbic system. Therefore, mechanistic insight is needed to understand the fundamental organization of sex hormone action on cortical