Single cell mapping the evolution of the spatial processing centre in the brain
Dorottya Ralbovszki, Mads Frost Bertelsen, Stamos Tahas, Yuki Mori, Jan Gorodkin, Martin Hemberg, Stefan Seemann, Konstantin Khodosevich, Vanessa Hall · FENS Forum 2024
The entorhinal cortex (EC) plays an important role in memory and navigational processes. The EC is part of the three-layered allocortex and interestingly, the structure in several cortical areas of the reptilian ancestor of mammals was three-layered as well. The EC is shown to be affected in Alzheimer’s disease already at preclinical stages. Furthermore, spatial disorientation is a characteristic cognitive symptom in patients suffering from Alzheimer’s disease. To learn about evolutionary similarities of the EC, we carried out single-nuclei RNA sequencing analysis on salmon telencephalon, frui
ePoster · Neuroscience