Topic: Cx43 hemichannels

High-grade gliomas (HGGs) include astrocytoma and glioblastoma. They are characterized by aggressiveness, intra- and inter-tumor heterogeneity, and infiltrating ability, decreasing the efficacy of resection and therapies. Glioma invasiveness depends on the dynamic interaction between glial cells, mainly microglia, and astrocytes. Accordingly, extra-CNS metastasis remains a rare clinical entity. Astrocytic connexin43 (Cx43) is under microglia control. Cx43-mediated signaling profoundly impacts HGGs invasion and could be a potential target in the glia-HGGs communication. However, it needs furthe

Glioblastoma is a highly malignant tumor with poor prognosis. Intercellular signaling has been proposed to be directly involved in glioblastoma proliferation, motility and invasion. In particular, (i) glioblastoma growth and infiltration are associated to deregulated astrocytes-neuron signaling; (ii) glioblastoma induces astrocytes function alterations leading to modification of the inter and intra cellular communication and neuronal hyperactivity and epileptic seizures; (iii) glutamate release in peri-tumoral region excite glutamate receptors on glioma cells promoting tumor growth and invasiv