Topic: cytokines

Neuroinflammation is a fundamental element of many neurodegenerative disorders. Activation of astrocytes and microglia cells leads to a release of cytokines and reactive oxygen species followed by leakage of the blood-brain barrier and neurotoxicity. Transient neuroinflammation is understood to be largely protective, chronic neuroinflammation, however, contributes to the pathology of Alzheimer’s disease, traumatic brain injury, and many more. In this study, we focus on the aspect of cytokine-induced neuroinflammation in human microglia cells and especially in astrocytes, since many studies on

Consequences of children brain exposure to radiation (doses ≤ 2 Gy) are not clearly established. The advent of computed tomography scans use for head exploration as well as a recent increase in the use of interventional neuroradiology in pediatrics raised the need to improve our knowledge of these effects. To understand how irradiation may affect the developing brain, we previously developed models of either whole brain or hippocampal dorsal dentate gyrus irradiation in ten-day-old male mice (doses ≤ 2 Gy) and demonstrated some alterations in adult mice behavior and in hippocampal neurogenesis

Alzheimer’s disease (AD) is the most common cause of dementia. Metabolic disorders, including prediabetes (preDM) and type two diabetes (T2D) increase the risk to suffer AD, and may contribute to dysfunctional brain insulin signaling and abnormal tau phosphorylation. Thus, we measured cortical tau phosphorylation at Ser-199, Ser-202/Thr-205, Ser-396, Ser-404, Thr-217 and Thr-231 residues in animals reproducing PreDM and T2D, alone or with AD. We analyzed the relationship between tau phosphorylation and metabolic profile, Aβ levels, microglia activation, cytokines production and cognitive impai