Topic: IL-6

We have developed a robotic platform allowing us to monitor cytokines dynamics (including IL-2, IFN-g, TNF, IL-6) of immune cells in vitro, with unprecedented resolution. To understand the complex emerging dynamics, we use interpretable machine learning techniques to build a generative model of cytokine response. We discover that, surprisingly, immune activity is encoded into one global parameter, encoding ligand antigenic properties and to a less extent ligand quantity. Based on this we build a simple interpretable model which can fully explain the broad variability of cytokines dynamics. We

Aims: Psychiatric morbidity and functional limitations are widespread in patients with thermal skin injury. Hyperbaric oxygen therapy (HBO) and antioxidant supplementation have been adjunctive therapy to promote wound healing. We evaluated the effects of HBO (100% O2 at 2.5 ATA for 60 minutes) and the antioxidant supplementation – Filipendula ulmaria (FU) extract (100 mg/kg b.w.), individually, in the treatment of anxiety-like behavior that occurs along the thermal skin injury in rat for seven days. Methods: Anxiety level estimation was performed in the open field and the elevated plus maze te