Topic: d1 receptors

Motor cortex (MCtx) comprise the primary descending circuits for flexible control of voluntary movements and plays an important role in motor skill learning. The proposed mechanism for motor learning and updating is dopaminergic modulation of local neuronal activity. However, little is known about the organization of dopaminoceptive circuits in the MCtx. Therefore, we targeted cells expressing D1 and D2 receptors in the MCtx and discovered that neurons located in the superficial layer 2/3 have D2 receptors, whereas the majority of cells in deep output layers 5-6 express D1 receptors. We then i

Interactions between conspecifics trigger the release of dopamine (DA), primarily from the ventral tegmental area (VTA) into the Nucleus Accumbens (NAc), promoting pleasure and positive reinforcement. Disruptions in DA levels can impact social motivation, potentially decreasing responsiveness to social reward and increasing the risk for social anxiety disorder.Using the social fear conditioning (SFC) paradigm, we investigated how DA regulates social motivation and its role in processing social fear. Our approach combined behavioural pharmacology and molecular techniques focusing on the VTA and