Topic: Data-Independent Acquisition

Transglutaminase 2 (TG2) is a widespread enzyme in the transglutaminase family, which consists of nine multifunctional proteins that evolved from the papain family. TG2 is ubiquitously expressed across various tissues and cell types. Its primary role is catalyzing the formation of a durable isopeptide bond through the Ca2+-dependent covalent linkage between the γ-carboxamide group of peptide-bound glutamine and the ε-amino group of lysine in proteins. This enzymatic process results in a proteolytically-resistant bond. Significantly, TG2 activity is observed to increase in several neurodegenera

Instinctive behaviours such as defence, feeding and reproduction have evolved across animal phyla and ensure survival of both the individual and its kin. A brainstem region central to the initiation of virtually all instinctive behaviours is the periaqueductal gray (PAG). Although stereotyped to some degree, the expression of instinctive behaviours exhibits significant variability within and across individuals. Previous work has mostly focussed on behavioural variability arising from plasticity mechanisms occurring in forebrain regions projecting to the PAG, including the hypothalamus, amygdal