Topic: dendritic spine loss

ePoster: 2 ePosters

CAP2 overexpression in hippocampal neurons prevents actin abnormalities and cognitive defects in an Alzheimer’s disease model

Ramona Stringhi, Filippo La Greca, Laura D'Andrea, Elisa Zianni, Lina Vandermeulen, Miriam Ascagni, Michela Carola Speciani, Valeria Edefonti, Diego Scheggia, Monica Di Luca, Silvia Pelucchi, Elena Marcello · FENS Forum 2024

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by Amyloid β (Aβ)-driven synaptic dysfunction in the early phases of pathogenesis. However, cytoskeletal abnormalities, such as cofilin-actin rods, have been described in AD patients. In addition, we demonstrated that the actin-binding protein Cyclase-associated protein 2 (CAP2) is a master regulator of cofilin synaptic localization through the Cys32-dependent CAP2 dimerization. The CAP2 dimer-mediated cofilin translocation is required for synaptic plasticity-driven spine remodelling.This mechanism is altered in AD since CA

ePoster · Neuroscience

Nicotinamide supplementation mitigates synaptic plasticity impairment and cognitive decline after tibial fracture surgery in aging mice

Tatiana Guncay, Jorge Concha-Cerda, Pamela Contreras, J. Brañes, Daniela P Ponce, Jamileth More, Genaro Barrientos, Cecilia Hidalgo, Felipe Salech · FENS Forum 2024

Post-operative delirium (POD) in elderly patients is associated with increased cognitive decline, morbidity, and mortality. Neuroinflammation and NAD+ imbalance contribute to POD. We investigated the imbalance of NAD+-consuming enzymes, particularly sirtuins and CD38, associated with neuroinflammation. Additionally, we examined Nicotinamide (NAM), a precursor of NAD+, for its potential to alleviate neuroinflammation and metabolic imbalance.Female C57BL/6J mice aged 20-22 months underwent tibial fracture surgery and received pre- and post-surgery NAM treatment. Neuroinflammation, synaptic plast

ePoster · Neuroscience