Topic: differential gene expression

Introduction: Fibromyalgia syndrome (FMS) represents a complex and challenging condition characterized by widespread pain and an intricate interplay of genetic and environmental factors. Artificial intelligence (AI) offers the possibility of using previous knowledge to understand the molecular underpinnings of pain in FMS. The goal of this study was to leverage this information for drug repurposing prediction, setting the basis for new Clinical Trials. Methods: This study employed an innovative comprehensive approach utilizing AI for a systematic screening of genetic, clinical, and drug-relate

Huntington’s disease (HD) is a genetic neurodegenerative disorder that can result in motor, mood and cognitive symptoms. HD pathophysiology has been linked to neuroinflammation, which is the presence of inflammatory mediators and reactive glial cells in the brain parenchyma. Many signalling pathways likely interact to propagate neuroinflammation and contribute to cell loss. Previous literature indicates that in the anterior cingulate cortex, cell loss and neuroinflammation are correlated with HD mood symptoms. This project gives insight into inflammation-related differential gene expression in