Topic: DNMT3a2

Persistence is a key characteristic of memory that relies on systems consolidation, a process classically defined as the gradual transfer of information from the hippocampus to the cortex for long-term memory storage. However, the underlying molecular mechanisms are unknown. DNA methylation can act as a long-term regulatory signal, therefore being a prime candidate to regulate memory duration and stabilisation within engrams– the physical substrate of a memory.Using contextual fear conditioning (CFC) and engram tagging tools in mice, we showed that reactivation of cortical engrams reflects sys

A de novo mutation in the DNA methyltransferase 3A gene (Dnmt3a) causes Tatton-Brown-Rahman syndrome (TBRS), a recently described genetic neurodevelopmental disorder that currently has no treatment. Patients display tall stature and intellectual disability. Dnmt3a encodes for the enzymes Dnmt3a1 and Dnmt3a2. These enzymes, according to literature as well as published and unpublished work from our lab, play a crucial role in memory formation in the adult hippocampus. However, how brain and neuronal function is affected in TBRS remains poorly understood. This project aims to bridge this gap of k