Topic: dopaminergic GPCRs

Octopuses are an emerging model organism in neurobiology due to their unique nervous system and capacity for intelligence. However, due to this novelty, nothing is currently known about many of their receptors, including those involved in neuromodulation. Given the historical significance of dopamine action in the brain and our recent findings implicating it as one of the three main neurotransmitters used in the optic lobe, we have chosen to explore dopaminergic GPCRs in Octopus vulgaris. We have identified approximately twenty candidate octopus monoamine GPCRs, utilising protein sequence simi