Administration of Enterococcus faecium L-3 reduces disease severity in EAE model in rats by modulating microbiota composition, gut micromorphology, and immune function
Alexander Trofimov, Elena Tarasova, Anna Matsulevich, Nadezhda Grefner, Maria Serebryakova, Igor Kudryavtsev, Elena Ermolenko, Irina Abdurasulova · FENS Forum 2024
Experimental autoimmune encephalomyelitis (EAE) is a laboratory model for multiple sclerosis (MS), an autoimmune disease characterized by chronic inflammation in the CNS, associated with demyelination and neurological disorders. Dysbiosis of the gut microbiota is a risk factor for MS. Probiotic strains can modulate the microbiota composition and are considered a therapeutic approach for MS.This study aimed to explore the therapeutic potential of Enterococcus faecium L-3 (E.faecium), a probiotic strain, in modulating gut microbiota, intestinal morphology, and immune responses within an EAE rat