Topic: ellagic acid

Ellagic acid (EA) is a natural compound characterized by neuroprotective potential, although it shows poor pharmacokinetic profile. A valid approach could be delivering the drug in non-ionic surfactant vesicles (NSVs) through the nose to brain (N2B) route. Our aim was to load EA inside NSVs and explore EA-NSVs capability, compared to free-EA, to restore the impairment induced by Aβ1-42 on synaptic plasticity through electrophysiological recordings in ex-vivo model.Empty and loaded NSVs were prepared, and a physicochemical characterization were carried out. We performed field and whole cell pat

Ellagic acid (EA) is a polyphenol that contributes to the nutraceutical properties of pomegranate. In the brain it was reported to control noradrenaline release. Recently, we demonstrated that EA binds α2 receptors (α2R), mimicking the full-agonist clonidine. The study was extended to Urolithins (URO) A, B and C which represent the main metabolites of EA in mammals, following a chronic (14 days) administration of an EA micro-formulation (EAm).“In vitro” studies were carried out on cortical and hippocampal synaptosomes isolated from control mice acutely exposed to the UROs, clonidine and yohimb