Topic: endocannabinoid receptors

Memories are evolving constructs prone to modifications. Here, we explore the temporal rules that determine whether memories are associated, by cooperation, or selected and lost, by competition. To tackle this question, we have built a conceptual model of the rules underlying synaptic cooperation and competition between the cortical and thalamic afferents to projection neurons of the lateral amygdala (LA), a circuit necessary for the formation of fear-conditioning memories. We found that heterosynaptic cooperation and competition between thalamic and cortical inputs to the LA follow a strict t

Intricate and extended mechanisms are in place to allow for repair following injuries of the peripheral nervous system (PNS), particularly at the neuromuscular junction (NMJ). Type 1 endocannabinoid receptors (CB1R) may be involved in the repair process owing to their presence in the PNS and at the NMJ and given their role in axonal growth and neuronal plasticity. Owing to the role of perisynaptic Schwann cells, glial cells at the NMJ, in the regulation of NMJ repair following injury, we postulate that CB1R participate in NMJ denervation and reinnervation processes and that this regulation may