Topic: endothelial cells

Examine how endothelial cells, smooth-muscle cells and pericytes establish vascular networks and sustain organ function through development and aging. Mechanistic sessions connect RNA and chromatin regulation with organelle signalling, mechanotransduction and tissue remodelling. Studies of vascular heterogeneity and inter-organ communication link these processes to malformations and disease, while imaging, multimodal omics and computational methods provide routes toward therapeutic discovery. 10–15 January: Sunday check-in starts at 14:00 and scientific introductions at 19:30; Friday departur

Brain aging leads to cognitive decline and is the main risk factor for sporadic forms of neurodegenerative diseases including Alzheimer’s disease. While brain cell- and tissue-intrinsic factors are likely key determinants of the aging process recent studies document a remarkable susceptibility of the brain to circulatory factors. Thus, blood borne factors from young mice or humans are sufficient to slow aspects of brain aging and improve cognitive function in old mice and, vice versa, factors from old mice are detrimental for young mice and impair cognition. We found evidence that the cerebrov