Enteric nervous system

…She describes research on the enteric nervous system and sickness responses, including a proposed reflex that could connect infection to longer-lasting symptoms and guide future work on biomarkers.

The involvement of the Enteric Nervous System (ENS), the gut’s brain, in digestive and neurological disorders is widely recognized and constitutes a novel target for diagnostic biomarkers and therapies. For example, Parkinson’s disease patients are now stratified according to gut-first or brain-first patterns that diverge in symptom progression. However, large-scale characterization of this neuronal network is often limited to dissected micrometer-scale samples that cannot reflect network changes. We present a method for 3D quantitative analysis of ENS morphology using fluorescence lightsheet

The involvement of the Enteric Nervous System (ENS) in digestive and neurological disorders is widely recognized and constitutes a novel target for diagnostic biomarkers and therapies. For example, Parkinson’s disease patients are now stratified according to gut-first or brain-first patterns that diverge in symptom progression. However, large-scale characterization of this neuronal network is often limited to local sampling that cannot reflect network dynamics. We present a new method for minimally invasive in-vivo intraluminal investigation of electrophysiological activity from the entire dis

…patterns of the visceral nervous system. As an example, we will discuss recent developments of thin, stretchable, wireless biosensor patches that can be embedded within routinely used medical adhesives for recording electrophysiologic patterns of the GI tract. We will also showcase recent developments in array signal processing that enable non-invasive tracking, and source localization, of the slow wave patterns associated with the GI tract.

…and its neurons as experimental systems. I will present some of our recent work, which has characterised the enteric nervous system of Drosophila, and has explored its physiological plasticity as well as that of the intestine itself. This work has uncovered unexpected sexual dimorphisms, intestinal contributions to reproductive success and metabolic cros