Epileptogenic zone

…suitable candidates and localizing the epileptogenic zone remain significant challenges. We introduce and evaluate the clinical utility of three advanced neuroimaging techniques developed at established epilepsy surgery centers in the pre-surgical assessment at the recently designated District Epilepsy Center, Kingston Health Sciences Center (KHSC).Methods: Patients in the pre-surgical pathway were discussed in multidisciplinary team (MDT) meetings (n

…Resection of the epileptogenic zone, although effective, is very invasive, risky and generates side effects. To develop a non-invasive and effective treatment, we evaluated the therapeutic potential of synchrotron-generated X-ray microbeams, an innovativ

…the diagnosis, the localization of the epileptogenic zone and the monitoring of treatment. The gold standard to detect IEDs is the visual inspection of EEGs, performed by clinical experts. However, this task is time-consuming, prone to human error and subjectivity, and suffers from intra and inter-observer variability.This motivates the development of automated IED detectors. Researchers have explored various methods, from classical signal

Over the past decade we have demonstrated that the fusion of subject-specific structural information of the human brain with mathematical dynamic models allows building biologically realistic brain network models, which have a predictive value, beyond the explanatory power of each approach independently. The network nodes hold neural population models, which are derived using mean field techniques from statistical physics expressing ensemble activity via collective variables. Our hybrid approach fuses data-driven with forward-modeling-based techniques and has been successfully applied to expla

Over the past decade we have demonstrated that the fusion of subject-specific structural information of the human brain with mathematical dynamic models allows building biologically realistic brain network models, which have a predictive value, beyond the explanatory power of each approach independently. The network nodes hold neural population models, which are derived using mean field techniques from statistical physics expressing ensemble activity via collective variables. Our hybrid approach fuses data-driven with forward-modeling-based techniques and has been successfully applied to expla

In epilepsy research, a holy grail has been the identification and understanding of the "epileptogenic zone" - operationally defined as the (minimal) area or region of the brain is indispensible for the generation of epileptic seizures. The identification of the epileptogenic zone is particularly important for surgical treatments of focal epilepsy patients, but I will highlight some recent clinical, experimental and theoretical work showing that it is also fundamentally linked with our understanding of epilepsy and seizures. I will conclude with a proposal for an updated understanding of the e

…found to be altered in tissue from the epileptogenic zone resected from adults with drug-resistan