Topic: extracellular action potentials

Advances in the development of microelectrode arrays (MEAs) for in-vitro electrophysiological recordings have enabled the characterization of multi-scale behavior in neuronal networks, ranging from subcellular level to network dynamics. Such devices are fundamental for studying the phenotype of neurological disorders and for drug discovery, providing unique insights into the complexity of neuronal networks. Electrode density, spacing, and size influence the signal quality, noise level, and sensitivity. To properly characterize the full behavior of neuronal networks, MEAs must combine single-ce

Human induced pluripotent stem cell (hiPSC)-derived neural models have emerged as invaluable tools for studying neurological disorders, such as epilepsy, Alzheimer’s, and Parkinson’s disease.Real-time, label-free measurement of electrical activity in self-organizing in vitro cellular models provides critical insight into the complexity of their neuronal networks. High-density microelectrode arrays (HD-MEAs) enable non-invasive electrophysiological recordings from various electrogenic samples, including iPSC-derived neurons, retinal explants, brain slices, and neural organoids.In this study, we