Topic: Ezrin

Aging differently affects cellular components of the brain active milieu. Here, we analyzed astrocytes and neurons in the neocortical access tissue of younger (22 - 50 years) and older (51 - 72 years) human who underwent resection of glioma or other cancer metastases to the brain. Aging decreased the amount of reduced mitochondrial cytochromes in astrocytes but not neurons. The protein-to-lipid ratio was decreased in astrocytes and increased in neurons. Aged astrocytes showed morphological dystrophy quantified by the decreased length of branches, decreased volume fraction of leaflets, and shri

For the nervous system to function properly, mature neurons must have a stable dendritic architecture. Mature neurons still possess the capacity for structural plasticity, which is necessary to facilitate adaptive processes such as memory formation. What molecular and cellular mechanisms regulate this fine balance between dendritic structural stabilization and plasticity is unknown. Aberrant connectivity is the consequence of atrophy or maladaptive plasticity, which fails to preserve the ideal dendritic structure and is linked to a number of neurological disorders. The upkeep of mature dendrit