Topic: first-episode psychosis

Schizophrenia (SZ) is a heterogeneous neuropsychiatric disorder whose complexity has hampered the identification of biomarkers that are actually useful in the clinical practice. Our study is based on the hypothesis that first-episode psychosis (FEP) patients present altered gene expression in blood that correlates with changes in neurons. We have analyzed the expression of genes (associated with SZ in genomic studies) through real-time PCR in peripheral blood from 63 FEP patients and 83 controls. We observed that TOX gene was significantly altered in male patients when compared to male control

Magnetic Resonance Imaging has advanced our understanding of the neuroanatomical basis of psychosis. However, persistent challenges, including underpowered datasets, recruitment difficulties, high costs, and an overrepresentation of Western populations, hinder progress. Here, we introduce the Psychosis MRI Shared Data Resource (Psy-ShareD), a new open-access repository that aims to address these challenges by harmonising MRI datasets from labs around the world, to build a large globally representative resource. Psy-ShareD provides easily accessible and curated data, allowing a wide variety of