Experimental model for strain-induced mechanical neurostimulation on human progenitor neurons
Erdost Yildiz, Mertcan Han, Linda Werneck, Marc-Andre Keip, Metin Sitti, Michael Ortiz · FENS Forum 2024
Aim: Although non-invasive, such as focused ultrasound stimulation, and invasive, such as neural interface implantations, neurological interventions on the brain are increasing in the clinics nowadays, there is no detailed experimental model of these mechanical effects on neurons. In this study, we built an experimental model to mimic mechanical strain stress on neurons and compared the experimental model's effectiveness with the existing literature. Methods: In this study, we designed unidirectional, bidirectional, and omnidirectional strain setups integrated with a high-speed camera. Neural