Topic: ultrasound stimulation

Ultrasound stimulation of the retina was proposed as an alternative to retinal prostheses for visual restoration. Prior works have shown that the retina responds to mechanical stimulation, but no attempt on stimulating an ex vivo retina with a free-standing photoacoustic membrane had yet been made. Here, we report ultrahigh precision stimulation of the retina with optically generated focused ultrasound (OFUS). OFUS is generated with a photoacoustic membrane of embedded carbon nanoparticles in polydimetylsiloxane. Using ex vivo multielectrode array recording and pharmalogical approaches, we inv

In a recent study in rodents in our team, we showed that sonogenetic therapy can be applied to stimulate the visual cortex (V1) at a high spatiotemporal resolution with ultrasound following the expression of the MscL mechanosensitive ionic channel. Moreover, we proved that sonogenetic activation of V1 can generate visual perception using an associative learning test.To develop sonogenetics as a vision restoration therapy the next step is to prove visual perception via sonogenetic stimulation in non-human primates (NHPs).Methods: In consequence, we proceeded to obtain retinotopic maps of NHP’s

In the pursuit of restoring vision for patients having lost the eye-brain connection, ultrasound stimulation is a new interesting therapeutic approach at the cortical level. In particular, Sonogenetic therapy has been explored as a mean to increase the sensitivity of cells to ultrasound by expressing a mechanosensitive ion channel in the membranes of cells of interest in order to modulate their activity.In order to optimize sonogenetics for vision restoration, we first focused on exploring the properties of different mechano-sensitive ion channels, the key parameters being the spatial and temp