Topic: FOSB

Intractable chronic itch is resistant to antihistamines, and difficult to treat, which significantly reduces quality of life. Here, we focused on GABA transporter 1 (GAT1) whose blockade might have an antipruritic effect by increasing endogenous GABA.The allergic contact dermatitis model of chronic itch was generated by applying 1-fluoro-2,4-dinitrobenzene (DNFB) onto the shaved neck skin using ICR male mice. Five days after sensitization by topical application of 50 µL 0.5% DNFB solution, mice were challenged repeatedly with 30 µL 0.25% DNFB solution on day 1, 3, 5, and 7. Scratching frequenc

Immediate-early genes (IEGs) are a class of activity-regulated genes (ARGs) that are transiently and rapidly activated in the absence of de novo protein synthesis in response to neuronal activity. We explored the role of IEGs in genetic networks to pinpoint potential drug targets for Alzheimer’s disease (AD). Using a combination of network analysis and genome-wide association study (GWAS) summary statistics we show that (1) IEGs exert greater topological influence across different human and mouse gene networks compared to other ARGs, (2) ARGs are sparsely involved in diseases and significantly