Topic: Foxo1

Astrocytes are active players in brain function. They sense and respond to neuronal activity by elevating intracellular calcium levels. These calcium elevations exhibit complex spatiotemporal patterns across the soma and main processes and focal microdomains. This activity underlies the astrocytic involvement in synaptic transmission, metabolism, and brain homeostasis. Here, we performed a multi-level analysis of the IP3 receptor type 2 knockout (IP3R2 KO) mouse model lacking global calcium elevations in astrocytes to disclose its implications to the molecular, cellular, and behavior levels. T

Parkinson's disease (PD) is a multifaceted neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons, predominantly within the substantia nigra pars compacta (SNc) region. Dysregulation of FoxO1 has been implicated in various neurodegenerative diseases, including Alzheimer's disease and PD, yet the precise underlying mechanisms remain largely elusive. In this study, we investigated the impact of α-synuclein pre-formed fibrils (PFF) treatment on BV-2 microglial cells to elucidate alterations in molecular properties and neuronal degeneration. Surprisingly, our find

Astrocytes are crucial for modulating synaptic activity and behavior through bidirectional communication with neurons. They sense and respond to neuronal activity by elevating intracellular calcium levels, which display complex spatiotemporal properties. To disclose its implications for behavior, we studied the IP3 receptor type 2 knockout (IP3R2 KO) mouse model that lacks global calcium elevations in astrocytes. We found that mice lacking IP3R2 display enhanced fear memory. Molecular analysis of hippocampal tissues revealed hundreds of up or down-regulated genes, among which 76 of those are m