Topic: GADD34

Neurons are highly plastic cells, altering the proteome to adapt to environmental cues. These changes are governed by fluctuations in protein synthesis pace and the nature of the mRNAs that are being translated. Although it is well established that de novo protein synthesis is fundamental to consolidate long-term memory, many details remain unknown, including the molecular mechanisms that trigger protein synthesis pace elevation that drive consolidation. Mounting evidence suggests that triggering long-term memory consolidation requires the release of the translation initiation brake, particula

Spinocerebellar ataxia type 2 (SCA2) is a rare neurodegenerative disease that arises from a mutation within the ATXN2 gene characterised by abnormally long CAG trinucleotide repeats. The mutant gene product is the ataxin-2 protein, which bears an expanded glutamine tract. The mutant protein is known to disrupt molecular pathways within cells, leading to cellular death and neurodegeneration within specific brain regions.To cope with disrupted pathways, cells have mechanisms such as the Integrated Stress Response (IRS), which help cells resolve stress situations by reorganising translation to pr