Gap junctions

Reinstating details of previously seen stimuli given a recall cue is a common cognitive function. Studies suggest that such recollection involves hippocampus-mediated top-down reactivation of neural ensembles active during encoding, yet the neural mechanisms of such generative retrieval remain unknown. We formulate a biologically plausible hypothesis where transient cholinergic modulation, known to enhance backpropagated action potentials and trigger recall, initiates backward signals from sparse neurons discriminatively representing the cue to cortical areas encoding the trace. These signals

…both inhibitory chemical synapses and gap junctions. These networks are essential for regulating neuronal activity notably by regulating temporally patterned dynamic states. We aim to understand the mechanisms that allow for synchronization to arise in networks of interneurons with both chemical synapses and electrical gap junctions (Panel 1). To this end, we use the exact mean-field reduction, often referred to as the “neural mass model” in the literature (Montbrio et al, PRX, 2015). We first analyse a sin

Advancements in machine learning have drastically improved our ability to fit biophysical models of neural systems. We present here a fully-differentiable, biophysical model of the mouse retina that is primed for gradient-based optimization. Our model is based on the Jaxley software library (Deistler et al. 2024, Bernstein Conference) and JAX machine learning framework. The model consists of a network of Hodgkin-Huxley style neurons, realistic synapse dynamics, an experimentally-informed organization of cells in 3D space, and spatially constrained connectivity. We further implemented a wide v

The primary olfactory cortex (piriform cortex) is a well-established epileptogenic site with the potential to amplify and generalize seizures. Disinhibition, caused by the synaptic inhibition of inhibitory neurons by other inhibitory neurons, increases the excitability of principal neurons and has been proposed as a contributing factor in numerous neurological diseases, including epilepsy. Therefore, unravelling inhibitory microcircuits in the piriform cortex may uncover new therapeutic avenues for treating epilepsy. Our study used whole-cell recordings from identified classes of inhibitory in

…as they are integral components of gap junctions, which facilitate direct cytoplasmic connections between neighboring cells. Recent studies identified clusters of connexins within the rodent CNS, specifically along the axon initial segment (AIS), a critical neuronal microdomain responsible for the initiation of action potentials. However, details about the subce

…altogether with the observed lack of gap junctions, suggest that the primary mechanism yielding early color-opponency in zebrafish is a dominant inhibitory feedback. The r

…for the presence of the requisite gap junctions and will explain how electrical coupling could account for very fast network oscillations at >80 hz.

…They are directly coupled by gap junctions formed in majority by neuronal Cx45. Coupling of axons, except known transpassing functions, allows to reduce axonal membrane resistance of optic nerve and accelerates transduction of visual signal. This novel finding have substantial implications for understanding of the pathogenesis of various optic neuropathies and identifies a new potential target for a