Electrical coupling of optic nerve axons - a novel model of gap junctions' involvement in optic nerve function
Monday, June 1, 2020
17:00 UTC
Dr Adrian Smedowski
Medical University of Silesia
Recording
Open recording
Hosted by neuroEYEscience70 minutes
Abstract
Axons in the optic nerve are arranged in bundles and conducting action potential with resistance related to their membrane. Optic nerve axons do not form absolutely independent conductive channels. They are directly coupled by gap junctions formed in majority by neuronal Cx45. Coupling of axons, except known transpassing functions, allows to reduce axonal membrane resistance of optic nerve and accelerates transduction of visual signal. This novel finding have substantial implications for understanding of the pathogenesis of various optic neuropathies and identifies a new potential target for a therapeutic approach.
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