Gastrointestinal diseases

…interactions play a critical role in gastrointestinal diseases. Sympathetic neural system (SNS) activity, susceptible to stress modulation, has been elucidated for its direct impact on immune cells through adrenergic receptors, or alternatively, its indirect influence via the modulation of proinflammatory chemical release. However, sympathetic neural-immune interactions in the gastrointestinal tract and their contribution to visceral pain are still unclear. Here, we established an early life stress model with gastrointestinal disorder. In t

Chronic pain is a leading cause of morbidity, common to patients with gastrointestinal diseases such as irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). Most pain killers are largely ineffective against this type of pain or restricted for use in these patients due to gut related complications and risk of addition. A significant unmet clinical need therefore exists to develop novel non-opioid based visceral analgesics.