Topic: genome sequencing

Many epilepsies remain unexplained after exome or genome sequencing. This workshop investigates mechanisms that conventional testing may miss: somatic mosaicism, repeat expansions, epigenetic changes and microRNA regulation. It relates biological and technical detection limits to neuronal excitability, clinical heterogeneity and treatment resistance. Thematic presentations and an interactive panel address multi-omics study design, clinical phenotyping, biomarkers and therapeutic development, connecting molecular mechanisms to precision medicine and surgical decisions. Sunday 6 December, 08:30

How can bacterial and viral pathogens rapidly evolve to become more or less harmful? Kayla King examines changes in virulence across the tree of life using evolutionary theory, genome sequencing and laboratory selection experiments. The lecture considers changes occurring within weeks in response to host immunity and warming temperatures, their consequences for pathogen genomes and host health, and what they imply for predicting virulence in a changing world. It connects the ecological and evolutionary dynamics of infection with the growing risk of zoonotic spillover into humans and protected