Genome-wide association studies

…It introduces genome-wide association studies, pleiotropy and polygenic risk scores, then considers their use in precision medicine. Outstanding limitations include unexplained heritability and the uneven representation of human populations in genomic research.

…Studies conducted on post-mortem tissue samples have characterized complex lesion types that diverge significantly on the composition of oligodendrocyte (OLG) lineage cells and their degrees of remyelination, both across different individuals and within each MS patient1. To date, the intrinsic genetic factors that potentially impact OLG-mediated de- and re-myelination in MS lesions,

…Additionally, data from Genome-Wide Association studies (GWAS) of relevant disorders were compared using Ingenuity Pathway Analysis (IPA) (Qiagen). IPA analysis of proteomic results showed dysregul

Translating insights from genome-wide association studies (GWASs) into practical therapies for depression poses a significant challenge. Our objective is to address this challenge by utilizing network-based algorithms on GWAS outcomes for drug repurposing. This approach aims to advance precision medicine, specifically focusing on East Asian populations.Our research involved an initial meta-analysis of GWASs to reveal genetic variants linked to depression, utilizing data from large-scale studies including the Taiwan Biobank (Ntotal: 19389) and BioBank Japan (Ntotal: 178630). We employed a rando

…including data from population studies, twin analyses and multiplex family studies. Initial molecular discoveries occurred via classical methods of linkage and gene identification. Recent l