Glia

…barrier, interactions with neurons and glia, and emerging therapeutic strategies.

The nucleus accumbens (NAc), a central hub in reward processing, intricately modulates emotional behaviours, including anxiety. A compound derived from the metabolization of polyphenols by the microbiota, mitobooster (MB) has been previously shown to improve mitochondrial function by promoting turnover of the dysfunctional mitochondria. In this study, we aimed to understand the effect of MB treatment in outbred rats that show high anxious-like behaviour. First, animals were grouped by their trait anxiety based on the amount of time spent in the open arms in the elevated plus maze test, and the

…An important role is played by glia which, among their homeostatic roles, also include modulation of neural stem cells and their progeny.We will share and discuss recent molecular, biochemical and pharmacological data supporting an important role of astroglial cells in the modulation of neurogenesis under both physiological and pathological conditions, including aging and neurodegeneration. Particularly, focus will be on the role of astrocytes and their

Ischemic stroke is one of the most serious and widespread neurological emergencies in the world. It is characterized by rapid disruption of brain blood flow, and it can cause irreversible damage to brain cells leading to permanent disability or death. Currently, treatment options are limited and fail to completely prevent or reverse brain damage. It is therefore essential to pursue innovative approaches to improve the prognosis and quality of life of ischemic stroke patients.Brain organoids are three-dimensional models that can reproduce the cellular composition, structure, and neuronal connec

…vehicles in primary rat neurons and glia as a prerequisite for further assessment in animal m

The mammalian neocortex is populated by different neuronal and glia cell types. During development, excitatory projection neurons and certain glia lineages emerge from radial glial progenitors (RGP). Impairments in RGP progenitor behavior and lineage progression can affect neuron production and maturation, leading to cortical malformations such as micro- or macrocephaly. The Notch signaling pathway instructs stem cell self-renewal and differentiation in a variety of tissues, including the brain. The Notch1 receptor is expressed in RGPs during embryonic development and maintains the progenitor

The SynAGE committee members are thrilled to host ISYNC, the International SynAGE conference on healthy ageing, on 28-30 March 2022 in Magdeburg, Germany. This conference has been entirely organised from young scientists of the SynAGE research training group RTG 2413 (www.synage.de) and represents a unique occasion for researchers from all over the world to bring together and join great talks and sessions with us and our guests. A constantly updated list of our speakers can be found on the conference webpage: www.isync-md.de. During the conference, attendees will have access to a range of symp

…Further, I will show how glia may h

…neurons, as well as small numbers of glia throughout life. Adult V-SVZ neural stem cells dynamically integrate intrinsic and extrinsic signals to either maintain the quiescent state or to become activated to divide and generate progeny. I will present our recent findings highlighting adult neural stem cell heterogeneity, including the identification of novel gliogenic domains and cell types, and the key roles of physiological state and long-range signals in the regula