Topic: Globus Pallidus internus

Deep Brain Stimulation (DBS) in the Globus Pallidus internus (GPi) is a therapeutic approach for various neurological disorders. Its effects on decision-making remain complex and not fully understood. The presented study uses a neuro-computational model of the basal ganglia to investigate how DBS influences decision-making by enhancing cortico-thalamic shortcuts and altering basal ganglia plasticity, particularly in the context of a probabilistic reversal-learning task. We adjusted our basal ganglia model parameters to replicate patient behavior data from Marcelino et al. (2023). Simulations