GLP-1 receptor agonists

…GLP-1 receptor agonists have drawn wide attention, and new small-molecule agonists with better brain penetration could extend their use beyond obesity and diabetes, including potential applications in addiction and dementia. The meeting also covers gene therapy, novel drug targets, psychedelics and new ways of delivering treatments across the blood-brain barrier. Speakers include Liam Grey (Professor of Functional Neurosurgery, Cardiff University

…projects on how FDA-approved GLP-1 receptor agonists influence drug seeking and reinstatement in rodents. A new NIH R01 aims to determine who becomes vulnerable to substance use disorders, when and why, using the aversive behavioural and neurochemical response to intraoral delivery of a drug-paired taste cue (conditioned withdrawal) to track the development of addiction in vulnerable male and female rats. It tests whether engaging homeostatic need substrates, as well as reward substrates, drives