Topic: glucocorticoid receptors

Early life adversity (ELA), defined as an adverse experience during critical periods in brain development, is a risk factor for neurodevelopmental and psychiatric disorders. The major effector molecules of stress are glucocorticoids (GCs), which by binding to glucocorticoid receptors (GRs) regulate several biological processes in the brain and the body. So far, little is known about the effects of ELA on a subtype of glial cells, named oligodendrocyte precursor cells (OPCs) or NG2-glia. To investigate how GCs can affect the molecular signature of the NG2-glia and impact the behavioral phenotyp

Rice bran extract (RBS) possesses a wide range of biological properties; however, its potential antidepressant effects and molecular mechanisms remain unclear. This study aimed to investigate the antidepressant effects of RBS in a mouse model of chronic stress (CS)-induced depression and anxiety and elucidate the underlying molecular mechanisms. Mice exposed to CS were administered RBS at different doses (250, 500, and 1000 mg/kg/body weight) for 5 weeks. The results demonstrated that RBS significantly improved depressive and anxiety symptoms, as evidenced by increased sucrose preference and r