Topic: glutamate receptors

Richard L. Huganir discusses research on the molecular mechanisms that regulate glutamate receptors, the brain's major excitatory neurotransmitter receptors, and thereby modulate communication between neurons.

Christophe Mulle is a cellular neurobiologist with expertise in electrophysiology of synaptic transmission and an international leader in studies on glutamate receptors and hippocampal synaptic plasticity. He was among the first to identify and characterize functional nicotinic receptors in the mammalian brain while working in the laboratory of Jean-Pierre Changeux at the Pasteur Institute. He then generated knock-out mice for KAR subunits at the Salk Institute in the laboratory of Steve Heinemann, which have proven to be instrumental for understanding the function of these elusive glutamate r

Neuronal networks derived from human induced pluripotent stem cells (hiPSCs) have gained attention for their potential use in in vitro modeling of epilepsy and seizure-like electrophysiological activity. Similar to in vivo animal models, seizure-like activity can be induced in these neuronal cultures using kainic acid (KA), direct agonist of the glutamate receptors. However, to establish more relevant in vitro model using KA, better understanding of KA mediated acute and prolonged effects on human neuronal networks is required. In this study, we investigated both acute and long-term KA concent

Mental disorders are the leading causes of disability worldwide. They comprise a broad range of conditions, including mood disorders, which are in general marked by a significant distress, emotional disturbances, social withdrawal and a loss of interest in normally rewarding activities. Stress is a key environmental factor that predisposes to many mood disorders, such as depression and hinders remission. The behavioral sequelae of stress partly result from enduring changes in striatal dopamine and glutamate transmission. Current therapies primarily target symptoms rather than their causes due

In drosophila neurons, information flows from the soma to the active zones, electron-dense regions decorated with conserved molecules, including BRP. BRP sits vis-a-vis postsynaptic Glutamate receptors. Despite comprehensive studies highlighting their importance in synaptic transmission, there has yet to be a study regarding the temporal dynamics of these molecules at drosophila neuromuscular junctions (NMJs) and their correlation with changes in locomotor patterns. In this study, we aimed to study the temporal dynamics of BRP and glutamate receptors via immunostaining and imaging. We quantita