Topic: glutathione

Ischemia reperfusion injury remains a significant challenge in various clinical settings, necessitating effective therapeutic interventions. Hypothermia has emerged as a promising strategy for mitigating cellular damage associated with oxygen deprivation. Our study investigates the molecular mechanisms underlying hypothermia-mediated protection using an in vitro model system. We demonstrate that hypothermia exerts a dual effect on cellular metabolism, simultaneously suppressing metabolic activity while enhancing stress tolerance. Specifically, mild hypothermia at 32°C emerges as the optimal te

Rett syndrome (RTT) is an early-onset neurological disorder that primarily affects females, causing severe cognitive and physical disabilities. Recently, an imbalance in redox homeostasis and exacerbated inflammatory response have been shown to play a central role in the diverse clinical manifestations of the disease.Numerous studies have highlighted that p75 neurotrophin receptor (p75NTR) may have a role in the regulation of oxidative stress (OS) and inflammation.Therefore, the aim of this work was to evaluate whether the modulation of p75NTR by LM11A-31 counteracts the alterations in OS and

Social status is key to mental health and well-being. The nucleus accumbens (NAc) regulates motivated behaviors, including the establishment of social hierarchies. Our recent work underscored NAc mitochondrial energy metabolism as critical for social competition among rodents. However, the exact neurochemical and molecular underpinnings of the differences in NAc energy metabolism and the specific contribution of distinct cell types are yet to be determined. Magnetic resonance spectroscopy (MRS) allows the study of metabolites related to energy metabolism, neurotransmission, and cellular integr