Glutathione peroxidase

The influence of psychosocial stress on antioxidant enzymes (AOE) in the central nervous system is associated with mood disorders. To unravel systemic effects of psychosocial stress we aimed to investigate AOE activity in peripheral organs and erythrocytes of peripubertal rats due to social isolation during peripuberty. Social play with peers during this period is highly rewarding activity abundant in the young of most mammalian species. Absence of peer social support is associated with depression. Male peripubertal Wistar Han rats were either group-housed (3/cage) or single-housed (1/cage) du

…on the activity of catalase (CAT), superoxidase dismutase (SOD) and glutathione peroxidase (GPx) in people with Parkinson's disease (PD). Participants and Methods: Volunteers were randomly divided into 2 groups: balance training (BTG, n=10, age 65.3±3.84 years) or control group (CON, n=10, age 66.8±2.38 years). For 12 weeks (3 times/week for 60 minutes), BT was conducted at an intensity of 60-70% of maximum heart rate. Before and after 12 weeks of BT, the activity of antioxidants enzymes was d

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, defined by motor neuron loss, muscle paralysis, and death. ALS individuals often present alterations in cardiovascular function that may evolve into heart failure and death. Mitochondrial dysfunction and oxidative stress are key players in ALS pathophysiology. Thus, improving mitochondrial function and/or antioxidant capacity constitute promising therapeutic strategies to delay ALS progression. We hypothesized that mitochondria-targeted antioxidant AntiOxCIN4 can reduce cardiac oxidative/nitrosative stress in SOD1G93A ALS mice