Topic: catalase

The influence of psychosocial stress on antioxidant enzymes (AOE) in the central nervous system is associated with mood disorders. To unravel systemic effects of psychosocial stress we aimed to investigate AOE activity in peripheral organs and erythrocytes of peripubertal rats due to social isolation during peripuberty. Social play with peers during this period is highly rewarding activity abundant in the young of most mammalian species. Absence of peer social support is associated with depression. Male peripubertal Wistar Han rats were either group-housed (3/cage) or single-housed (1/cage) du

The aim of the authors’ research was to assess the effect of moderate‐intensity balance training (BT) on the activity of catalase (CAT), superoxidase dismutase (SOD) and glutathione peroxidase (GPx) in people with Parkinson's disease (PD). Participants and Methods: Volunteers were randomly divided into 2 groups: balance training (BTG, n=10, age 65.3±3.84 years) or control group (CON, n=10, age 66.8±2.38 years). For 12 weeks (3 times/week for 60 minutes), BT was conducted at an intensity of 60-70% of maximum heart rate. Before and after 12 weeks of BT, the activity of antioxidants enzymes was d

Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder, following Alzheimer's disease. It is characterized by the degeneration of dopaminergic neurons in the SNpc, resulting in both motor and non-motor symptoms. Current treatments are limited, and PD's molecular basis involves alpha-synuclein aggregation, ubiquitination dysregulation, and oxidative stress. Nicotine, found in tobacco, has been associated with reduced PD risk in epidemiological studies and shown neuroprotective effects in animal models. However, its impact on oxidative stress remains unclear. A study in

Oligodendrocytes (OLs) myelinate axons and are essential for fast impulse propagation and the brain’s remarkable processing power. They also carry out important homeostatic support functions that are critical for maintaining long-term neuronal integrity. Mitochondrial reactive oxygen species (ROS) are implicated in various neurodegenerative diseases and influence cell functions in a cell-specific manner, yet the (patho)physiological impact of oligodendroglial ROS on neural functions remains unknown. To study the impact of oligodendroglial ROS in aging and disease, we generated mice (termed OL-