Topic: glyceraldehyde

Perturbations in brain cell metabolism are consistently interwoven with neurodegenerative disorders like Alzheimer's disease (AD)(1). In particular, dysfunctions of mitochondrial bioenergetics incite severity of AD pathology (2), whereas proof-of-concept evidence indicates that glutamate can feed mitochondrial ATP synthesis, thereby preventing deadly derangements in Ca2+ and redox homeostasis in different neurodegenerative models (3;4).In this work, we tested a pharmacological approach to stimulate the glutamate dehydrogenase (GDH) function with the allosteric activator 2-Aminobicyclo-(2,2,1)-

A growing body of evidence emphasizes that hypometabolism taking place in astrocytes may compromise their physiological neuro-supportive role and activate a set of pathophysiological pathways contributing to the progression of neurodegenerative diseases, including Alzheimer disease (AD) [1]. Here, we explored the potential role of astrocytes in driving a cascade of detrimental effects in the neighboring neurons and investigated a possible approach to limit the injury in both cell types [2]. To this aim, primary rat cortical astrocytes were exposed to glyceraldehyde (GA) to induce a metabolic s