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Topic: glycerophospholipids

ePoster
2 ePosters

In Neuroscience

The hippocampal lipid alterations in an Alzheimer's disease model

Elif Keskinoz, Musa Celik, Ezgi Sila Toklucu, Kerem Birisik, Mesut Bilgin, Devrim Oz Arslan · FENS Forum 2024

Our aim is to investigate the effect of choline, fish oil, and uridine-5'-monophosphate (UMP) supplementation on lipid profiles in the 5XFAD mouse model of Alzheimer's disease (AD) was to characterize cholesterol, glycerophospholipids (GPLs), sphingolipids (SLs), glycolipids (GLs), lysophospholipids (lyso GPLs) and lysophospholipid acyltransferases (lyso GPL O-ATs), and glycerophospholipid (GPL Os).Lipidomic analysis was performed on hippocampal brain tissue samples from 3-, 6- and 9-month-old 5XFAD mice and littermate controls using cutting-edge mass spectrometers with direct infusion (shotgu

ePoster · Neuroscience

Multi-omics approach identified a network of lipids and proteins associated with lysosomal and mitochondrial metabolism in Parkinson’s disease patients carrying mutations in TMEM175 gene

Federica Carrillo, Marco Ghirimoldi, Giorgio Fortunato, Nicole Piera Palomba, Laura Ianiro, Antonietta Di Lorenzo, Veronica De Giorgis, Sara Pietracupa, Nicola Modugno, Elettra Barberis, Marcello Manfredi, Teresa Esposito · FENS Forum 2024

In this study we investigated whether the presence of mutations in TMEM175 gene could reflect a characteristic lipidomic, metabolomic and proteomic signature of PD patients both at circulating and cellular levels.The study cohort included two groups of patients that differ for the presence of TMEM175 mutations, and a group of matched controls. We adopted an untargeted omics approach to disclose lipidomic, metabolomic and proteomic alterations in PD patients carrying TMEM175 mutations both in plasma and dermal fibroblasts.Integrated analysis of omics data revealed wide deregulation of lysosome,

ePoster · Neuroscience