Topic: glycine receptors

Pharmacotherapy for Alcohol Use Disorder (AUD) may be improved by targeting mechanisms by which alcohol interferes with dopamine (DA) pathways in the reward circuitry. Alcohol acts on inhibitory glycine receptors (GlyR) in the nucleus Accumbens (nAc) and treatment with GlyR agonists raise basal DA, attenuate alcohol-induced DA release in the nAc and reduce alcohol intake in rats. Combined treatment with varenicline+bupropion produces additive effects on nAc DA output and abolishes the alcohol deprivation effect (ADE) in rats, predictive of clinical efficacy. This study examines whether the gly

Optimal brain function relies upon the delicate equilibrium between excitatory and inhibitory neurotransmission. A slight disturbance in this equilibrium can trigger significant neurological disorders. In the mature brain, glycine assumes a dual responsibility by not only coordinating inhibitory processes through the activation of classical pentameric glycine receptors (pGlyRs), but also contributing to excitatory neurotransmission in its capacity as a co-agonist of N-methyl-D-aspartate receptors (NMDARs). The functional impact of glycine through pGlyRs has been extensively scrutinised, partic