Topic: graft survival

Stroke is a leading cause of disability and death due to the brain’s limited ability to regenerate damaged circuits. Induced pluripotent stem cell (iPSC)-based therapies are emerging as a promising therapeutic approach for stroke recovery. Here, we demonstrate that local transplantation of GMP-compatible iPSC-derived neural progenitor cells (NPCs) improve long-term recovery-associated brain tissue responses and reduce neurological deficits after cerebral ischemia in mice. Using in vivo imaging and post-mortem histology, we showed long-term graft survival over the course of five weeks and prefe

Every three seconds, someone suffers a stroke, a major contributor to global mortality and disability. Stroke survivors often face limited treatment options and significant disabilities. Stem cell therapy holds promise for brain regeneration and functional recovery, yet it's hindered by poor graft survival post-transplantation due to the hostile stroke environment. Our goal is to enhance graft survival and regenerative potential through cell acclimatization using sublethal hypoxic preconditioning or functionalized, compressible cryogel microcarriers. A protocol for obtaining injectable cryogel