Stroke

…affecting women and girls, including stroke. Eligible approaches span biomedical mechanisms, clinical investigation, health services, population health and data science. Awards begin from July 2027 and support three-year projects.

…It spans stroke, traumatic injury, concussion and rehabilitation, linking laboratory work with clinical services and policy. A patient-journey case study examines gaps from emergency retrieval through rehabilitation and long-term community care. Sessions explore data harmonisation, co-design, exercise-related cognition, peer support and translation into practice. Project showcases include AI-supported vocational training, virtual-reality rehabilitation, post-stroke stimulation,

…across a range of conditions including stroke, vascular malformations, and brain tumors. With broader clinical adoption, its practical strengths — as well as important limitations — have become increasingly clear.

…In the event of stroke or other injury to these systems, neural circuits reorganize in an attempt to restore lost function. However, the neural processes and learned representations underlying language network reorganization remain unclear. Here, we present data from a first-of-its-kind human case study involving chronic intracortical recordings from the right cerebral hemisphere of a patient with non-fluent aphasia with severe left-hemispheric

Prolonged reduction in blood flow leads to stroke, a devastating neurological insult leading cause of adult disability worldwide. One of the early features of stroke is the disruption of neuronal activity that results from the reduction of metabolic supply. Changes in oscillatory brain patterns have been observed in several neurological disorders, including stroke. Evoked neural oscillations in the gamma range have recently shown the ability to restore and maintain intrinsic homeostatic processes in the brain. However, the causal relationship between stimulation and restoration of function is

Stroke is a leading cause of long-term disability worldwide with substantial economic costs. Hence, there is an urge for finding novel therapies to treat disability associated to stroke. This is the main reason research has focused on the discovery of key molecules involved in the functional prognosis of patients after stroke. Adenosine A2A and CB2 are receptors that have proven to be a new therapeutic target to consider in treatment of stroke. A common feature of these receptors in neurons is that their expression is upregulated in neuroinflammation process. On the one hand CB2R show a neurop

After stroke, one of the most critical problems for recovering patients is motor dysfunction in the limb contralateral to the affected hemisphere. Several mechanisms may contribute to the recovery of motor function after stroke. One is the recovery of neural pathways within the affected hemisphere. The contribution of the ipsilateral hemisphere is also widely discussed as it may be entirely responsible for motor recovery. The lateralized readiness potential (LRP) is one of the markers of interhemispheric balance during motor preparation. It is a fast negative deflection approximately 200 ms be

Stroke is the main cause of adult disability in developing countries. There is a need for identifying new signalling pathways involved in stroke pathogenesis to discover potential therapeutic strategies for stroke. We previously found that the E3 ubiquitin ligase APC/C-Cdh1 promotes neurogenesis, proliferation, and neuronal survival, which are essential events for brain repair after stroke. APC-Cdh1 also regulates protein levels of the dendrite stabilizer Rock2. Thus, the APC/C-Cdh1-Rock2 axis modulates dendrite elongation and synaptogenesis. However, whether Cdh1 plays a role in stroke remain

Aims: Stroke disrupts neural communications in the brain. The resulting network disruption may cause disabilities after stroke. The aim of this study was to examine whether the remaining networks can underlie a higher-order cognitive process in stroke. Methods: Fifty-eight stroke patients were studied using a measure of the intellectual capacity to reason by spatial analogy (Raven’s Coloured Progressive Matrices [RCPM]), and functional connectivity revealed by resting-state functional magnetic resonance imaging (rfMRI). A connectome-based analysis was performed on rfMRI data to examine whole-b

Stem cell therapy has emerged as a promising strategy for treating stroke, but it still presents several challenges, such as the optimal administration route or safety concerns. In clinical practice, endovascular delivery of cells is preferred to intracerebral injection. However, circulating stem cells must cross the blood-brain barrier (BBB) and might get trapped in peripheral organs, resulting in an insufficient number of cells reaching the lesion. To optimize their migration across the BBB, we aimed to mimic immune cells as they extravasate into the brain parenchyma following injury. For in

…rehabilitation in patients affected by stroke. The present study aims to demonstrate the effectiveness of Action Observation (AO) combined with VR (AO+VR) in upper limb stroke rehabilitation, as compared to a control treatment based on VR alone (CO+VR). A multicentric randomized controlled trial (RCT) with blinded assessment and two investigative arms was conducted. Adult stroke survivors with hemiplegia (N=26) were randomized into AO+VR or CO+VR treatment groups. The treatment consisted

Stroke is a major cause of long-term disability worldwide, however, current therapeutics are limited. Decreases in neuronal oscillatory power, particularly in the gamma frequency band, are commonly seen following ischemia. Previous research in mice has demonstrated that optogenetic stimulation in this gamma frequency range, specifically at 40Hz, is beneficial for recovery post-stroke. However, this treatment option is not easily translated to human patients. Here we investigated the effects of 40Hz non-invasive electrical brain stimulation as a potential therapeutic to restore motor impairment

Gut microbiome has strongly emerged as a pivotal factor in the pathogenesis of stroke via gut-brain axis. However, it remains uncertain whether interventions that modulate gut microbiome can constitute a potent strategy to improve stroke outcome. The present study was carried out to explore interventions that affect stroke outcome through gut-brain axis.Eligibility criteria was applied base on PICO to search and select studies. Appropriate MESH-terms were used as search terms to source for information from PubMed, Web of Science, Cochrane Library, Ebsco, and Scopus from 1st January 1990 to 31s

Stroke remains a leading cause of long-term disability, with effective therapies hampered by an incomplete understanding of brain recovery mechanisms. Emerging evidence indicates that the interactions between the brain extracellular matrix (ECM) and glial cells1 critically contribute to post-stroke neuroplasticity and can help promote stroke recovery.We investigated the role of perineuronal nets (PNNs), facet-like ECM layers surrounding fast-spiking interneurons, in neurological recovery following focal cerebral ischemia in mice. Using superresolution stimulated emission depletion (STED), stru

Stroke is one of the main reasons of acquired epilepsy in adults. Little is known about the underlying pathomechanisms that occur during epileptogenesis, so between the transient hypoxia and the first late seizure.Some transcription factors drive gene-expression towards an epileptogenic phenotype through channelopathies, which may be acquired through brain insults, such as the T-type Ca2+ channel CaV3.2.Hypoxia-inducible factor 1α (HIF-1α) is quickly activated and can bind to the promoter of CaV3.2, potentially inducing an epileptogenic cascade in penumbra neurons.We used NS20Y cells and prima

Stroke is a leading cause of disability and death due to the brain’s limited ability to regenerate damaged circuits. Induced pluripotent stem cell (iPSC)-based therapies are emerging as a promising therapeutic approach for stroke recovery. Here, we demonstrate that local transplantation of GMP-compatible iPSC-derived neural progenitor cells (NPCs) improve long-term recovery-associated brain tissue responses and reduce neurological deficits after cerebral ischemia in mice. Using in vivo imaging and post-mortem histology, we showed long-term graft survival over the course of five weeks and prefe

Stroke is one of the major reasons for death and disability. Insufficient blood flow in stroke interferes the brain from proper oxygenation, leading to the stabilization of hypoxia-inducible factors (HIFs). To determine the role of HIFs in stroke, particularly HIF-2α, an in vivo model called tMCAO (transient middle cerebral artery occlusion) and an in vitromodel with human SH-SY5Y cells was used. On both, Hif-2α deficient and wild type mice, tMCAO was conducted for two hours. In addition to RNA and protein samples, tissue for immunofluorescence microscopy was collected of ischemic and control

Acid-sensing ion channel 1 (ASIC1) is a trimeric ion channel, opened by a fast drop of extracellular pH. ASIC1 is highly abundant in the CNS and present at the postsynapse. In slice recordings of the lateral amygdala, it was shown, that ASIC1 can be activated by protons co-released by transmitter exocytosis, thus contributing to synaptic transmission. Intriguingly, ASIC1-dependent current was small compared to currents of GABA or Glutamate receptors, however, ASIC1 was reported to have a significant impact on various physiological and pathophysiological processes e.g. fear related behavior, lo

…is recognized as a risk factor for stroke. Tet2 mutations exerted the greatest influence on complex cardiovascular endpoints in a study of incident strokes. The aim of this preclinical study was to explore if mutant HSC exhibit an aggressive phenotype, releasing pro-inflammatory cytokines and causing more damage to the penumbra area, heart, endothelial cells, and the blood-brain barrier (BBB). One-leg irradiated mice grafted into with WT or Tet2-/- (induced knockout) chimeric bone marrow were subjected t

Every three seconds, someone suffers a stroke, a major contributor to global mortality and disability. Stroke survivors often face limited treatment options and significant disabilities. Stem cell therapy holds promise for brain regeneration and functional recovery, yet it's hindered by poor graft survival post-transplantation due to the hostile stroke environment. Our goal is to enhance graft survival and regenerative potential through cell acclimatization using sublethal hypoxic preconditioning or functionalized, compressible cryogel microcarriers. A protocol for obtaining injectable cryogel

Current rehabilitation for stroke primarily relies on physiotherapy. Research has found that serotonin plays a crucial role in the neuroplastic processes required for brain reorganisation after a stroke. We investigated whether modulation of serotonergic transmission of the dorsal raphe nucleus (DRN), together with rehabilitation training, leads to an improvement in motor recovery.In a photothrombotic stroke mouse model, lesion volume and localization were assessed following 24h after ischemia with 7T-MRI. We chemogenetically activated or inhibited the DRN through adeno-associated virus (AAV)

Spreading Depolarizations (SDs) are electrographic events that arise post-stroke and correlate with worsening outcome. The haemodynamic response to SD is vasodilation in well perfused tissue. However, SDs induce hypoperfusion in ischemic tissue, further decreasing the viability of ‘at risk’ tissue.Traditional metal-based electrodes are limited in their ability to faithfully record DC-coupled potential shifts including SD. In contrast, Graphene micro-transistor arrays (gSGFETs) precisely record SDs without signal attenuation, distortion or voltage drift; and their transparency allows simultaneo

Acquired brain injuries (ABIs), such as stroke and traumatic brain injury (TBI), represent global health challenges, stroke ranking as the third leading combined cause of death and disability, and TBI contributing to over 7 million disability-adjusted life years. Functional recovery in ABIs is influenced by age, older individuals showing poorer recovery. Axonal plasticity, a form of structural neuroplasticity, holds promise for understanding and promoting recovery. Injuries were carried out in 14-month-old male Wistar rats. Focal stroke was induced by unilateral intracerebral administration of

Disruption of the blood-brain barrier (BBB) is a key factor in the development of stroke. N,N-dimethyltryptamine (DMT) is a hallucinogen alkaloid widely found in plants and animals. Beneficial effects of DMT was described in a rat stroke model, but BBB functions were not studied. Our aim was to examine the effect of DMT on the functions of the BBB following oxygen-glucose deprivation and reoxygenation (OGDR) in a rat primary BBB co-culture system.To model stroke in vitro, OGD was introduced for 6 hours on the BBB model, followed by reoxygenation for 24 hours with or without the addition of DMT