Topic: GSK-3β

Alzheimer’s disease (AD) is the most common neurodegenerative disorder, which is characterized by a progressive loss of neuronal cells in different brain’s regions, that lead to a functional cognitive impairment. Neurofibrillary tangle (NFT) is a primary biomarker of AD, which is formed by an abnormal accumulation of hyper phosphorylated Tau protein inside the neuronal cells. Effective treatment for neurodegenerative diseases (NDs) presents a clinical challenge. Natural products showed a promising role in treatment of neurodegenerative diseases (NDs). Geniposide is a natural extract from the f

The deposition of amyloid-β (Aβ) peptides has been implicated as a one of pathological hallmark of Alzheimer's disease (AD). Increasing evidence indicates that Aβ initiates oxidative stress and a vicious cycle of mitochondrial damage, leading to apoptotic neuronal death. Pinocembrin (5,7-dihydroxyflavone), a major flavonoid found in honey and propolis, has shown significant neuroprotective property by suppressing Aβ cleaving enzyme in our previous study. The present study investigated a novel anti-AD effect of pinocembrin on mitochondrial dysfunction and apoptosis against Aβ injury. Neurotoxic

Down syndrome (DS) individuals are characterized by a variety of pathological phenotypes that manifest with wide variability in different tissues. In the central nervous system, the accelerated aging phenotype is associated with the risk of developing Alzheimer-like dementia. A central aspect of neurodegeneration is the close association between metabolic disorders and cognitive decline. Multiple studies have suggested a link between metabolic disorder and microRNAs (miR), small non-coding RNAs acting as post-transcriptional regulators of a plethora of genes. Among triplicated miRNAs on chromo