Topic: H3K4me3

Spinal cord injury (SCI) is a devastating condition of the CNS for which there are no restorative therapies. Neuronal death at the primary lesion site and in remote regions that are functionally connected to it is one of the major contributors to neurological deficits induced by SCI. In this study we examined the crosstalk between mitochondria and the epigenome, defined as “mitonuclear communication” and its contribution to the remote damage-induced by SCI in the red nucleus (RN) contralateral to the injury site. Using a mouse model of SCI, we performed RNA-seq analysis on RN isolated from con

Loss of function mutations in genes encoding lysine methyltransferases responsible for trimethylation of histone 3 on lysine 4 (H3K4me3) are associated with a range of neurodevelopmental conditions. Intriguingly, mutations of H3K4me3-specific lysine demethylases (KDMs) are also associated with autism and intellectual disability. Mutations in KDM5B have been reported in patients with autism, intellectual disability and developmental delay. We hypothesised that a deficiency in the demethylation activity of KDM5B will lead to a dysregulated H3K4me3 epigenome, abnormal neurodevelopmental gene expr