Topic: HDAC4

Temporal lobe epilepsy (TLE) is a neurological disorder associated with spontaneously recurrent seizures with about 30% of the patients exhibiting pharmacoresistant. Thus, it is imperative to understand the molecular mechanisms underlying the pathogenesis of TLE to develop an effective treatment strategy. Several neurological disorders are associated with Histone deacetylase 4 (HDAC4) dysregulation, but its specific molecular substrates and the precise mechanism by which it contributes to TLE are unknown. Thus, in our study, we used the lithium-pilocarpine model of TLE and samples resected fro

Early dysfunction in Alzheimer's disease (AD) is characterized by abnormal synapse structure and function. We investigated the role of the class II member HDAC4, which controls synaptic plasticity and memory, as potential new modulator of synaptic function in AD. HDAC4 localization and function was assessed in hippocampal tissue from adult control (WT) and 3×Tg mice (AD) by confocal analyses, co-IP and biochemical fractioning. The effects of the overexpression of a cytoplasmic mutant form of HDAC4 (HDACSD) or the empty vector were analyzed in cultured hippocampal neurons or organotypic brain s