Topic: hierarchical clustering

The striking diversity of cells in the mammalian brain lies in stark contrast with the uniformity of cells in theoretical models and artificial networks. What computational advantage do these myriad cell types provide? Deciphering their roles first requires organizing cells in the appropriate manner. Typically, cells are organized into a hierarchical clustering of cells into cell types. This approach is based on a rich history of cell typing based on morphology and other accessible correlates. However, the very large-scale datasets enabled by advances in DNA sequencing potentially may reveal a

The prefrontal cortex (PFC) plays an important role in working memory [1], however, the underlying neural processes remains elusive. Studies on the hippocampus revealed that place cell sequences encode goal-directed behavior in rats [2]. In this study, we report about the existence of sequential activation patterns in PFC and their correlation with behavior in a working memory task. Experiments were conducted with one-photon calcium imaging in Thy1-GCaMP6f mice during an olfaction-guided spatial memory task in a three-arm arena consisting of sampling, choice, and reward conditions. In order to

The fusiform gyrus (FG) in the human brain is essential for higher cortical functions such as recognizing faces and human bodies [1, 2]. Though, the relationship of its structural and functional decompositions in the anterior portion is yet to be better understood [3]. Here, the anterior FG was investigated in ten postmortem brains (five female, five male, including the BigBrain [4]). Using a reproducible, histologically based and software-supported approach, digitized coronal histological brain sections were analyzed [5-7]. A "Grey Level Index" method was used to determine cytoarchitectonic b

Spontaneous activity of neuron populations is often characterized by unique network events, ranging from sharp-wave ripples to slow propagating waves. One of the prominent examples of such network events is population bursting (Fig. 1a), robustly emerging in networks of primary neurons in vitro [1]. Population bursting is believed to depend on the genetic, single neuron, and network features. Typically, the events are characterized via several summary statistics and compared between observations [2]. Although changes in the burst morphology are frequently observed, they are much harder to quan

The striatum intricately regulates motor and cognitive functions through the dynamic interplay of dopamine (DA), acetylcholine (ACh), and intrinsic neuronal firing, bearing profound implications for disorders like Parkinson's. However, the interaction between striatal DA and ACh, and their collective impact on striatal neuron activity in health and disease, are not fully understood. This study aims to elucidate the complex interplay between ACh, DA, and neuronal activity in the striatum during sensory and motor events. Utilizing a specialized Delayed-Go reaching task for head-fixed mice, we re