Topic: Hierarchical clustering

The prefrontal cortex (PFC) plays an important role in working memory [1], however, the underlying neural processes remains elusive. Studies on the hippocampus revealed that place cell sequences encode goal-directed behavior in rats [2]. In this study, we report about the existence of sequential activation patterns in PFC and their correlation with behavior in a working memory task. Experiments were conducted with one-photon calcium imaging in Thy1-GCaMP6f mice during an olfaction-guided spatial memory task in a three-arm arena consisting of sampling, choice, and reward conditions. In order to

The fusiform gyrus (FG) in the human brain is essential for higher cortical functions such as recognizing faces and human bodies [1, 2]. Though, the relationship of its structural and functional decompositions in the anterior portion is yet to be better understood [3]. Here, the anterior FG was investigated in ten postmortem brains (five female, five male, including the BigBrain [4]). Using a reproducible, histologically based and software-supported approach, digitized coronal histological brain sections were analyzed [5-7]. A "Grey Level Index" method was used to determine cytoarchitectonic b

Spontaneous activity of neuron populations is often characterized by unique network events, ranging from sharp-wave ripples to slow propagating waves. One of the prominent examples of such network events is population bursting (Fig. 1a), robustly emerging in networks of primary neurons in vitro [1]. Population bursting is believed to depend on the genetic, single neuron, and network features. Typically, the events are characterized via several summary statistics and compared between observations [2]. Although changes in the burst morphology are frequently observed, they are much harder to quan