Topic: hippocampal development

Chromatin remodelling plays an essential role in development, for instance by controlling gene expression during cell differentiation. Mutations of chromatin remodellers are often implicated in developmental diseases such as CHARGE syndrome, in which a heterozygous mutation of the chromatin remodeller CHD7 is the major driver of the disease. To investigate the role of Chd7 during brain development, we used a dorsal telencephalon-specific Chd7 loss-of-function mouse model and discovered Chd7 acts as a multi-lineage coordinator. Histological analysis of Chd7 mutant mice shows that upon ablation

Voltage-gated sodium channels (Navs) play an integral role in brain function and development, enabling the generation and transmission of electrical signals with implications for neuronal excitability, synapse formation, and circuit establishment. Despite the distinct spatiotemporal expression of Navs, the understanding of their regulation in the developing brain is limited. Here we investigated the involvement of microRNAs (miRNAs), short non-coding RNAs, in the post-transcriptional regulation of sodium channel subunit expression. We carried out Argonaute sequencing on mouse hippocampal tissu