Topic: hippocampal neurogenesis

In addition to maintaining a healthy body, physical activity benefits the brain, improving memory and cognition. While some of the physiological effects of voluntary exercise on the brain are known (e.g., increased hippocampal neurogenesis), little is known about its effects on the neural code. Using longitudinal Ca2+ imaging in freely behaving mice and tracking the same neurons over weeks, we studied how voluntary exercise affects the quality and long-term stability of hippocampal place codes. In addition to increasing neurogenesis, we found that running accelerated the emergence of spatial c

During embryonic and postnatal development of the dentate gyrus (DG), neural stem cells (NSCs) proliferate, migrate and generate mature granule neurons. Unlike other brain regions, NSCs remain in the adult DG, mostly in a state of deep quiescence, with the ability to re-enter cell cycle and generate new neurons throughout life. The transitions back and forward from a proliferative state to a temporal shallow quiescence or primed state ensure the maintenance of stem cell population. However, it is unclear when and how adult NSCs acquire quiescence sub-states during development. Recently, we hav

The Bosch-Boonstra-Schaaf optic atrophy syndrome (BBSOAS; OMIN#615722), is a rare neurodevelopmental disorder caused by mutations in the NR2F1 gene, a transcriptional regulator playing pleiotropic functions in brain development. Most NR2F1 pathological variants are deletions and/or mutations leading to haploinsufficiency or dominant negative effects. Although BBSOAS is characterized by a wide array of clinical features, intellectual disability (ID), visual impairment, and autism spectrum disorder (ASD) are predominant. Notably, NR2F1 is identified as a risk gene for ASD (SFARI database), sugge

Type 2 diabetes mellitus (T2DM) is associated with a nearly 2-fold increased risk of Alzheimer's disease (AD) development although the reasons for this are unknown. Recent studies have reported dysregulated hippocampal neurogenesis in AD patients during postmortem examinations. Additionally, impaired neurogenesis has been observed in T2DM mouse models, suggesting this could explain the connection between T2DM and AD. This study aims to investigate how exposure to fatty acids associated with T2DM affects neuronal differentiation, serving as a model of neurogenesis. Human SH-SY5Y neuroblastoma c

Post-traumatic stress disorder (PTSD) can develop after exposure to severe traumatic event. PTSD is associated with changes in behavior and reduced neurogenesis. Available data suggests that antipsychotics or enriched environment may positively affect behavioral outcomes and increase neurogenesis in PTSD patients. Our aim was to determine whether aripiprazole, enriched environment or their combination in the PTSD animal model will positively affect behavioral outcomes and hippocampal neurogenesis. We used the single prolonged stress paradigm to induce PTSD related symptoms in animals. Animals

Introduction: Early life stress (ELS) might produce long lasting changes in hippocampal neurogenesis and increase the vulnerability to stress-related disorders later in adulthood. Objective: The analysis of immature granule cell densities in the hippocampal dentate gyrus (DG) between male and female mice subjected to ELS. Methods: Female and male C57BL/6J mice were subjected to 3h daily maternal separation (MS) for 21 days since birth. In day 60, mice underwent a single 2h restriction stress (RS) and sacrificed 24 hours after. The experimental groups were: Control, RS, MS, MS+RS. The DG was an

Consequences of children brain exposure to radiation (doses ≤ 2 Gy) are not clearly established. The advent of computed tomography scans use for head exploration as well as a recent increase in the use of interventional neuroradiology in pediatrics raised the need to improve our knowledge of these effects. To understand how irradiation may affect the developing brain, we previously developed models of either whole brain or hippocampal dorsal dentate gyrus irradiation in ten-day-old male mice (doses ≤ 2 Gy) and demonstrated some alterations in adult mice behavior and in hippocampal neurogenesis

Early Life Stress (ELS) can result in enduring health consequences, highlighting the need for exploring timely intervention approaches. Our study aims to investigate whether metformin, a long-recognized diabetes medication with neuroprotective and neurotrophic potential, can mitigate ELS-induced disruptions in hippocampal neurogenesis and dendritic growth. To test this hypothesis, both male and female neonatal Wistar rats were allocated into four distinct groups: control, metformin treatment, ELS model, and ELS model with metformin treatment (ELS+M). During the initial two weeks, ELS model was

Previous reports showed that many cognitive deficits arise in patients exhibiting symptoms of urinary tract infections (UTI) including neuropsychiatric disorders. In our laboratory, we have shown that E-coli induced UTI in adult rats caused a significant decrease in neurogenesis and impaired cognitive and memory skills. No studies have explored the mechanism of action and the effect of chronic inflammation mimicking UTI on neurogenesis and brain plasticity. Here, we aim to investigate the effect of chronic peripheral inflammation via lipopolysaccharide (LPS) instillation in the urothelium on c

Numerous reports have correlated lysine deficiency with cognitive decline; however, the effect of lysine deficiency on hippocampal neurogenesis has not yet been addressed in the literature. This study hypothesizes the impairment of hippocampal neurogenesis and thus hippocampal-related functions due to mild and severe induced dietary lysine deficiency. Here, we aim to observe the effect of mild and severe lysine deficiency on rodents' cognitive functions, memory, and adult hippocampal neurogenesis. In this project, male adult Sprague-Dawley rats were divided into three randomized groups (8 rats