Topic: hippocampal sharp-wave ripples

Liset de la Prida discusses hippocampal sharp-wave ripples and their relationship to replay and memory. The conversation connects different ripple patterns and neuron types to population activity, asking how particular cells help shape the lower-dimensional dynamics used to describe neural computation.

The brain continuously receives vast amounts of information from the rest of the body and the environment, only a fraction of which can be consciously processed and stored in memory. It is believed that hippocampal sharp-wave ripples tag memories that are relevant and should be remembered (Yang et al 2024). However, this selection of relevant information must occur already during sensory processing to avoid overloading the system with irrelevant information. The hypothesis of this project is that short bursts of high gamma activity, referred to as cortical ripples to distinguish them from hipp